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Ching-Hsuan Tung

Professor & Yushan Fellow

Molecular medical imaging, fluorescence chemistry Drug design, nanomedicine

✉ 信箱：chinghtung@gmail.com         ☎ 電話：06-2757575-65339

Education

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BS in Chemistry, National Cheng Kung University (1983)

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PhD in Chemistry, Rutgers-The State University of New Jersey (1992)

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Post Doc in Biotechnology, University of Medicine and Dentistry of New Jersey (1992)

Experience

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1992-1994 Center for Advanced Biotechnology and Medicine, University of Medicine and                             Dentistry of New Jersey, Research Associate

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1994-1997 Department of Gene Delivery, GeneMedicine, Inc, Senior Scientist

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1997-1998 Center for Molecular Imaging Research, Department of Radiology, Harvard Medical                     School, Massachusetts General Hospital, Senior Research Scientist

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1998-2003 Center for Molecular Imaging Research, Department of Radiology, Harvard Medical                     School, Massachusetts General Hospital, Assistant Professor of Chemistry in Radiology

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2003-2007 Center for Molecular Imaging Research, Department of Radiology, Harvard Medical                     School, Massachusetts General Hospital, Associate Professor of Chemistry in Radiology

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2009-2022 Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell                         Medical College, Cornell University, Professor of Chemistry in Obstetrics and                               Gynecology

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2009-2022 Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell                         Medical College, Cornell University, Professor of Chemistry in Radiology    

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2009-2022 Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell                         Medical College, Cornell University, Alexander R. Margulis Distinguished Professor in                   Radiology

2024-Present Visiting Professor & Yushan Fellow

Publications

  1. Lee, S. K.*; Han, M. S.; & Tung, C. H.* “In vivo senescence imaging nanoprobe targets the associated reactive oxygen species.” Nanoscale, 2024, 16(3), 1371-1383.

  2. Qi, J.; Zeng, Z.; Chen, Z.; Nipper, C.; Liu, X.; Wan, Q.; Tung, C. H.; ... & Zu, Y.* “Aptamer–gemcitabine conjugates with enzymatically cleavable linker for targeted delivery and intracellular drug release in cancer cells.” Pharmaceuticals, 2022, 15(5), 558.

  3. Lee, S. K.; Shen, Z.; Han, M. S.; & Tung, C. H.* “Developing a far-red fluorogenic beta-galactosidase probe for senescent cell imaging and photoablation.” RSC advances, 2022, 12(8), 4543-4549.

  4. Chen, X.; Lee, S. K.; Song, M.; Zhang, T.; Han, M. S.; Chen, Y. T.; Tung, C. H.*; ... & Du, Y. C. N.* “RHAMMB-mediated bifunctional nanotherapy targeting Bcl-xL and mitochondria for pancreatic neuroendocrine tumor treatment.” Mol Ther Oncolytics., 2021, 23, 277-287.

  5. Zhang, W.*; Du, B.; Gao, M.; & Tung, C. H.* “A hybrid nanogel to preserve lysosome integrity for fluorescence imaging.” ACS nano, 2021, 15(10), 16442-16451.

  6. Tung, C. H.*; Han, M. S.; Shen, Z.; Gray, B. D.; Pak, K. Y.; & Wang, J. “Near-infrared fluorogenic spray for rapid tumor sensing.” ACS Sens., 2021, 6(10), 3657-3666.

  7. Shen, Z.; & Tung, C. H.* “Selective photo-ablation of glioma cells using an enzyme activatable photosensitizer.” Chem. Commun., 2020, 56(89), 13860-13863.

  8. Bellat, V.; Alcaina, Y.; Tung, C. H.; Ting, R.; Michel, A. O.; Souweidane, M.; & Law, B.* “A combined approach of convection-enhanced delivery of peptide nanofiber reservoir to prolong local DM1 retention for diffuse intrinsic pontine glioma treatment.” Neuro-oncology, 2020, 22(10), 1495-1504.

  9. Du, B.; & Tung, C. H.* “Enzyme-assisted photodynamic therapy based on nanomaterials.” ACS Biomater. Sci. Eng., 2020, 6(5), 2506-2517.

  10. Zeng, Z.; Tung, C. H.; & Zu, Y.* “Aptamer-equipped protamine nanomedicine for precision lymphoma therapy.” Cancers, 2020, 12(4), 780.

  11. Lee, S. K.; Law, B.; & Tung, C. H. “Multifunctional nanodelivery platform for maximizing nucleic acids combination therapy.” Methods Mol Biol., 2020, 2115, 79-90.

  12. Lee, S. K.; Han, M. S.; Zhang, W.; & Tung, C. H.* “Multilayered Activatable Nanoprobe for Ultra‐Bright Tumor Imaging. Macromol Biosci., 2019, 19(12), 1900260.

  13. Du, B.; Zhang, W.; & Tung, C. H.* “A multiresponsive nanohybrid to enhance the lysosomal delivery of oxygen and photosensitizers." Chemistry., 2019, 25(55), 12801-12809.

  14. Du, B.; Zhang, W.; & Tung, C. H.* “Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy.” Chem Commun., 2019,  55(42), 5926-5929.

  15. Ramchandani, D.; Lee, S. K.; Yomtoubian, S.; Han, M. S.; Tung, C. H.; & Mittal, V. “Nanoparticle delivery of miR-708 mimetic impairs breast cancer metastasis.” Mol Cancer Therapy., 2019, 18(3), 579-591.​

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