Lai, Szu-Hsueh
Assistant Professor
Physical and Analytical Chemistry
Mass Spectrometry
Laser Chemistry and Spectroscopy
Instrumentation Development
✉ Email：shlai@gs.ncku.edu.tw
☎ Phone：06-2757575-65355
Education
BS in Chemistry, National Tsing Hua University (2005)
MS in Chemistry, National Tsing Hua University (2007)
PhD in Chemistry, National Taiwan University (2017)
Experience
2017-2018 Genomics Research Center, Academia Sinica,
Postdoctoral researcher
2018-2020 Interdisciplinary Research Institute of Grenoble (IRIG),
Commissariat à l'énergie atomique (CEA),
Postdoctoral researcher
2020-2022 Department of Pharmaceutical Sciences, Utrecht University,
Postdoctoral researcher
2022-Present Department of Chemistry, National Cheng Kung University,
Assistant Professor
Publications
1.
Lai, S.H.; Reynaud, A.; Zhang, N.N.; Kwak, M.; Vysotskyi, B.; Dominguez-Medina, S.; Fortin, T.; Clement, K.; Defoort, M.; Lee, T.G.; Liu, K.; Hentz, S.; Masselon, C.D.*"Characterizing Nanoparticle Mass Distributions Using Charge- Independent Nanoresonator Mass Spectrometry" J. Phys. Chem. C, 2022, 126, 49, 20946–20953.
2.
den Boer, M. A.; Lai, S.-H.; Xue, X.; van Kampen, M. D.; Bleijlevens, B.; Heck, A. J. R. "Comparative Analysis of Antibodies and Heavily Glycosylated Macromolecular Immune Complexes by Size-Exclusion Chromatography Multi-Angle Light Scattering, Native Charge Detection Mass Spectrometry, and Mass Photometry" Anal Chem, 2022, 94, 2, 892-900.
3.
Yin, V.**; Lai, S.-H.**; Caniels, T. G.; Brouwer, P. J. M.; Brinkkemper, M.; Aldon, Y.; Liu, H.; Yuan, M.; Wilson, I. A.; Sanders, R. W.; van Gils, M. J.; Heck, A. J. R. "Probing Affinity, Avidity,Anticooperativity,
and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses" ACS Central Science, 2021, 7, 11, 1863-1873.( ** Co-first author)
4.
Lai, S.-H.**; Tamara, S.**; Heck, A. J. R. "Single-particle mass analysis of intact ribosomes by mass photometry and Orbitrap-based charge detection mass spectrometry" iScience, 2021, 24, 11.( ** Co-first author)
5.
Lai, S.-H.; Chu, M.-L.; Lin, J.-L.; Chen, C.-H. " Development of a focused high-energy macromolecular ion beam" Analyst, 2021, 146, 9, 2936-2944.
6.
Greisch, J.-F.; den Boer, M. A.; Lai, S.-H.; Gallagher, K.; Bondt, A.; Commandeur, J.; Heck, A. J. R.
"Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining Regions" Anal Chem, 2021, 93, 48, 16068-16075.
7.
Fortin, T.; Vysotskyi, B.; Defoort, M.; Reynaud, A.; Lai, S. H.; Dominguez-Medina, S.; Clement, K.; Cumaku, V.; Hentz, S.; Masselon, C. "A Nonlinear Model for Nano-Electro Mechanical Mass Sensing Signals Processing" IEEE Sensors Journal, 2021, 21, 19, 21852-21861.
8.
Clement, K.; Reynaud, A.; Defoort, M.; Vysotskyi, B.; Fortin, T.; Lai, S.-H.; Çumaku, V.; Dominguez-Medina, S.; Hentz, S.; Masselon, C. "Requirements and attributes of nano-resonator mass spectrometry for the analysis of intact viral particles" Analytical and Bioanalytical Chemistry, 2021, 413, 29, 7147-7156.
9.
Chuang, Y.-K.; Lai, S.-H.; Lin, J.-L.; Chen, C.-H. "Biomolecular Clusters Distribution up to Mega Dalton
Region Using MALDI-Quadrupole Ion Trap Mass Spectrometer" International Journal of Molecular Sciences, 2018, 19, 9, 2789.
10.
Ozdemir, A.; Lin, J. L.; Gulfen, M.; Lai, S. H.; Hsiao, C. J.; Chen, N. G.; Chen, C. H. "ESI MS for Microsized
Bioparticles" Anal Chem, 2017, 89, 24, 13195-13202.