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Lai, Szu-Hsueh

Assistant Professor

Physical and Analytical Chemistry
Mass Spectrometry
Laser Chemistry and Spectroscopy
Instrumentation Development

✉ Email：shlai@gs.ncku.edu.tw

☎  Phone：06-2757575-65355

Education

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​BS in Chemistry, National Tsing Hua University (2005)

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​MS in Chemistry, National Tsing Hua University (2007)

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​​PhD in Chemistry, National Taiwan University (2017)

Experience

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2017-2018       Genomics Research Center, Academia Sinica,

                      Postdoctoral researcher

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2018-2020       Interdisciplinary Research Institute of Grenoble (IRIG),

                      Commissariat à l'énergie atomique (CEA),

                      Postdoctoral researcher

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2020-2022       Department of Pharmaceutical Sciences, Utrecht University,

                      Postdoctoral researcher

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2022-Present   Department of Chemistry, National Cheng Kung University,

                      Assistant Professor

Publications

  1. Lai, S.-H.*; Maclot, S.; Antoine, R.; Masselon, C. D.* "Advances in Single Particle Mass Analysis." Mass Spectrometry Reviews 2024.

  2. Fortin, T.*; Reynaud, A.; Jeudy, S.; Lai, S. H.; Çumaku, V.; Abergel, C.; Hentz, S.; Masselon, C. "Modeling Nanoelectromechanical Resonator Signals for Experimental Mass Measurements: A Total Variation Formulation." IEEE Access 2024, 12, 187919-187946. 

  3. Chang, K.-K.; Ko, Y.-Y.; Chou, P.-Y.; Lai, S.-H.; Wang, Y.-S.* "MAXTOF: An efficient calculation tool for precise optimization of MALDI-TOF MS measurements in real time." Journal of the Chinese Chemical Society 2024, 71 (8), 932-941.

  4. Oskam, N.; den Boer, M. A.; Lukassen, M. V.; Ooijevaar-de Heer, P.; Veth, T. S.; van Mierlo, G.; Lai, S.-H.; Derksen, N. I. L.; Yin, V.; Streutker, M.; Franc, V.; Šiborová, M.; Damen, M. J. A.; Kos, D.; Barendregt, A.; Bondt, A.; van Goudoever, J. B.; de Haas, C. J. C.; Aerts, P. C.; Muts, R. M.; Rooijakkers, S. H. M.; Vidarsson, G.; Rispens, T.*; Heck, A. J. R.* "CD5L is a canonical component of circulatory IgM." Proceedings of the National Academy of Sciences 2023, 120 (50), e2311265120.

  5. Lai, S. H., Reynaud, A., Zhang, N. N., Kwak, M., Vysotskyi, B., Dominguez-Medina, S., Fortin, T., Clement, K., Defoort, M., Lee, T. G., Liu, K., Hentz, S., & Masselon, C. D.* "Characterizing Nanoparticle Mass Distributions Using Charge-Independent Nanoresonator Mass Spectrometry." Journal of Physical Chemistry C 2022, 126 (49), 20946-20953.

  6. den Boer; M. A.; Lai, S. H.; Xue, X.; van Kampen, M. D.; Bleijlevens, B.; & Heck, A. J. R.* "Comparative Analysis of Antibodies and Heavily Glycosylated Macromolecula; Immune Complexes by Size-Exclusion Chromatography Multi-Angle Light Scattering, Native Charge Detection Mass Spectrometry, and Mass Photometry." Analytical Chemistry 2022, 94 (2), 892-900.

  7. Greisch, J. F.; den Boer; M. A.; Lai, S. H.; Gallagher, K.; Bondt, A.; Commandeur, J.; & Heck, A. J. R.* "Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining Regions." Analytical Chemistry 2021, 93 (48), 16068-16075.

  8. Lai, S. H.†, Tamara, S.†, & Heck, A. J. R.* "Single-particle mass analysis of intact ribosomes by mass photometry and Orbitrap-based charge detection mass spectrometry." iScience 2021, 24 (11), [103211].

  9. Yin, V.†; Lai, S. H.†; Caniels, T. G.; Brouwer; P. J. M.; Brinkkemper, M.; Aldon, Y.; Liu, H.; Yuan, M., Wilson; I. A.; Sanders, R. W.; Van Gils, M. J.; & Heck, A. J. R. "Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses." ACS Central Science 2021, 7 (11), 1863-1873.

  10. Fortin, T.*; Vysotskyi, B., Defoort, M., Reynaud, A., Lai, S. H., Dominguez-Medina, S., Clement, K., Cumaku, V., Hentz, S.; & Masselon, C. "A Nonlinear Model for Nano-Electro Mechanical Mass Sensing Signals Processing." IEEE Sensors Journal 2021, 21 (19), 21852-21861.

  11. Clement, K.; Reynaud, A.;Defoort, M.; Vysotskyi, B.; Fortin, T.; Lai, S. H.; Çumaku, V.; Dominguez-Medina, S.; Hentz, S.* & Masselon, C.* "Requirements and attributes of nano-resonator mass spectrometry for the analysis of intact viral particles." Analytical and Bioanalytical Chemistry 2021, 413 (29), 7147-7156.

  12. Lai, S. H.; Chu, M. L.; Lin, J. L.* & Chen, C. H. "Development of a focused high-energy macromolecular ion beam." Analyst 2021, 146 (9), 2936-2944.

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