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Lai, Szu-Hsueh

Assistant Professor

Physical and Analytical Chemistry
Mass Spectrometry
Laser Chemistry and Spectroscopy
Instrumentation Development

☎  Phone:06-2757575-65355



​BS in Chemistry, National Tsing Hua University (2005)


​MS in Chemistry, National Tsing Hua University (2007)


​​PhD in Chemistry, National Taiwan University (2017)



2017-2018       Genomics Research Center, Academia Sinica,

                      Postdoctoral researcher


2018-2020       Interdisciplinary Research Institute of Grenoble (IRIG),

                      Commissariat à l'énergie atomique (CEA),

                      Postdoctoral researcher


2020-2022       Department of Pharmaceutical Sciences, Utrecht University,

                      Postdoctoral researcher


2022-Present   Department of Chemistry, National Cheng Kung University,

                      Assistant Professor



Lai, S.H.; Reynaud, A.; Zhang, N.N.; Kwak, M.; Vysotskyi, B.; Dominguez-Medina, S.; Fortin, T.; Clement, K.; Defoort, M.; Lee, T.G.; Liu, K.; Hentz, S.; Masselon, C.D.*"Characterizing Nanoparticle Mass Distributions Using Charge- Independent Nanoresonator Mass Spectrometry" J. Phys. Chem. C2022, 126, 49, 20946–20953.


den Boer, M. A.; Lai, S.-H.; Xue, X.; van Kampen, M. D.; Bleijlevens, B.; Heck, A. J. R. "Comparative Analysis of Antibodies and Heavily Glycosylated Macromolecular Immune Complexes by Size-Exclusion Chromatography Multi-Angle Light Scattering, Native Charge Detection Mass Spectrometry, and Mass Photometry" Anal Chem, 2022, 94, 2, 892-900.


Yin, V.**; Lai, S.-H.**; Caniels, T. G.; Brouwer, P. J. M.; Brinkkemper, M.; Aldon, Y.; Liu, H.; Yuan, M.; Wilson, I. A.; Sanders, R. W.; van Gils, M. J.; Heck, A. J. R. "Probing Affinity, Avidity,Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses" ACS Central Science, 2021, 7, 11, 1863-1873.( ** Co-first author)


Lai, S.-H.**; Tamara, S.**; Heck, A. J. R. "Single-particle mass analysis of intact ribosomes by mass photometry and Orbitrap-based charge detection mass spectrometryiScience, 2021, 24, 11.( ** Co-first author)


Lai, S.-H.; Chu, M.-L.; Lin, J.-L.; Chen, C.-H. " Development of a focused high-energy macromolecular ion beam" Analyst, 2021, 146, 9, 2936-2944.


Greisch, J.-F.; den Boer, M. A.; Lai, S.-H.; Gallagher, K.; Bondt, A.; Commandeur, J.; Heck, A. J. R."Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining Regions" Anal Chem, 2021, 93, 48, 16068-16075.


Fortin, T.; Vysotskyi, B.; Defoort, M.; Reynaud, A.; Lai, S. H.; Dominguez-Medina, S.; Clement, K.; Cumaku, V.; Hentz, S.; Masselon, C. "A Nonlinear Model for Nano-Electro Mechanical Mass Sensing Signals Processing" IEEE Sensors Journal, 2021, 21, 19, 21852-21861.


Clement, K.; Reynaud, A.; Defoort, M.; Vysotskyi, B.; Fortin, T.; Lai, S.-H.; Çumaku, V.; Dominguez-Medina, S.; Hentz, S.; Masselon, C. "Requirements and attributes of nano-resonator mass spectrometry for the analysis of intact viral particles" Analytical and Bioanalytical Chemistry, 2021, 413, 29, 7147-7156.


Chuang, Y.-K.; Lai, S.-H.; Lin, J.-L.; Chen, C.-H. "Biomolecular Clusters Distribution up to Mega Dalton Region Using MALDI-Quadrupole Ion Trap Mass Spectrometer" International Journal of Molecular Sciences2018, 19, 9, 2789.


Ozdemir, A.; Lin, J. L.; Gulfen, M.; Lai, S. H.; Hsiao, C. J.; Chen, N. G.; Chen, C. H. "ESI MS for Microsized Bioparticles" Anal Chem, 2017, 89, 24, 13195-13202.


賴思學; 陳建弘; 林俊利; 陳仲瑄, 高創意質譜技術之發展與應用. 化學 2016, 74 (3), 183-201.

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