Lee, Yen-chun
Assistant Professor
Biochemistry
Chemical Biology
Education
BS in Chemistry, National Tsing Hua University (2008)
MS in Chemistry, National Tsing Hua University (2010)
PhD in Chemical Biology, Technical University Dortmund (2018)
Experience
2019-2021 Massachusetts Institute of Technology, Postdoctoral Researcher
2021-Present National Cheng Kung University, Assistant Professor
Publications
1.
Ye, X.Y.*; Lee, Y.C.*; Gates, Z.P.; Ling, Y.J.; Mortensen, J.C.; Yang, F.S.; Lin, Y.S.; Pentelute, B.L.* " Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions" Communications Chemistry, 2022, 5, 128.
2.
Pomplun, S.; Jbara, M.; Quartararo, A.J.; Zhang, G.W.; Brown, J.S.; Lee, Y.C.; Ye, X.Y.; Hanna, S.; Pentelute, B.L.* " De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein" ACS Cent. Sci., 2021, 7, 1, 156-163.
3.
C. M. Fadzen; J. M. Wolfe; W. Zhou; C.-F. Cho; N. von Spreckelsen; K. T. Hutchinson; Y.-C. Lee; E. A. Chiocca; S. E. Lawler; O. H. Yilmaz; S. J. Lippard*; B. L. Pentelute* "A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain" J. Med. Chem. 2020, 63, 13, 6741-6747.
4.
Y.-C. Lee; L. Knauer; K. Louven; C. Golz; C. Strohmann; H. Waldmann*; K. Kumar* "Gold(I)‐catalyzed and Nucleophile‐guided Ligand‐directed Divergent Synthesis" Eur. J. Org. Chem. 2018, 41, 5688.
5.
Y.-C. Lee; K. Kumar* "Gold(I) catalyzed enyne cycloisomerization – a roadmap to privileged heterocyclic scaffolds" Isr. J. Chem. 2018, 58, 531.
6.
Y.-C. Lee; K. Kumar*; H. Waldmann* " Ligand-directed divergent synthesis of carbo- and heterocyclic ring systems" Angew. Chem. Int. Ed. 2018, 57, 5212.
7.
H.-R. Wu; Y.-C. Lee* "The synthetic approach and logic of design behind the small molecule compound library synthesis" Chemistry (Chinese Chemical Society, Taipei) 2017, 75, 267.
8.
P.-K. Tsou; Y.-C. Lee; T. Lankau; M. Isobe; C.-H. Yu* " Substituent effects in the Nicholas epimerization of glycosides" J. Phys. Org. Chem. 2017, e3780.
9.
Y.-C. Lee; S. Patil; C. Golz; C. Strohmann; S. Ziegler; K. Kumar*; H. Waldmann* " A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity" Nat. Commun. 2017, 8, 14043.