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Lee, Yen-chun

Assistant Professor

Biochemistry
Chemical Biology

Email:yenchunlee.chem@gmail.com

         ycl_lab@gs.ncku.edu.tw

☎ Phone:06-2757575-65327

Education

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BS in Chemistry, National Tsing Hua University (2008)

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MS in Chemistry, National Tsing Hua University (2010)

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PhD in Chemical Biology, Technical University Dortmund (2018)

Experience

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2019-2021 Massachusetts Institute of Technology, Postdoctoral Researcher

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2021-Present  National Cheng Kung University, Assistant Professor

Publications

1.

Jimenez-Macias, J. L.; Lee, Y. C.; Miller, E.; Finkelberg, T.; Zdioruk, M.; Berger, G.; Lawler, S. E. "A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma" J. Control. Release 2022352, 623. 

2.

Ye, X.Y.*; Lee, Y.C.*; Gates, Z.P.; Ling, Y.J.; Mortensen, J.C.; Yang, F.S.; Lin, Y.S.; Pentelute, B.L.* " Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions" Communications Chemistry, 2022, 5, 128.

3.

Pomplun, S.; Jbara, M.; Quartararo, A.J.; Zhang, G.W.; Brown, J.S.; Lee, Y.C.; Ye, X.Y.; Hanna, S.; Pentelute, B.L.* " De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein" ACS Cent. Sci., 2021, 7, 1, 156-163.

4.

C. M. Fadzen; J. M. Wolfe; W. Zhou; C.-F. Cho; N. von Spreckelsen; K. T. Hutchinson; Y.-C. Lee; E. A. Chiocca; S. E. Lawler; O. H. Yilmaz; S. J. Lippard*; B. L. Pentelute* "A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain" J. Med. Chem. 2020, 63, 13, 6741-6747.

5.

Y.-C. Lee; L. Knauer; K. Louven; C. Golz; C. Strohmann; H. Waldmann*; K. Kumar* "Gold(I)‐catalyzed and Nucleophile‐guided Ligand‐directed Divergent Synthesis" Eur. J. Org. Chem. 2018, 41, 5688.

6.

Y.-C. Lee; K. Kumar* "Gold(I) catalyzed enyne cycloisomerization – a roadmap to privileged heterocyclic scaffolds" Isr. J. Chem. 2018, 58, 531.

7.

Y.-C. Lee; K. Kumar*; H. Waldmann* " Ligand-directed divergent synthesis of carbo- and heterocyclic ring systems" Angew. Chem. Int. Ed. 2018, 57, 5212.

8.

H.-R. Wu; Y.-C. Lee* "The synthetic approach and logic of design behind the small molecule compound library synthesis" Chemistry (Chinese Chemical Society, Taipei) 2017, 75, 267.

 9.

P.-K. Tsou; Y.-C. Lee; T. Lankau; M. Isobe; C.-H. Yu* " Substituent effects in the Nicholas epimerization of glycosides" J. Phys. Org. Chem. 2017, e3780.

10​ .

Y.-C. Lee; S. Patil; C. Golz; C. Strohmann; S. Ziegler; K. Kumar*; H. Waldmann* " A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity" Nat. Commun. 20178, 14043.

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