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Yeh, Chen-Sheng

Distinguished Chair Professor

1. Synthesis and formation mechanism of nanomaterials

2. Design of functional nanomaterials

3. Applications of nanomaterials:

(1) Biomedical image

(2) Drug carrier and drug delivery

(3) Therapy in cancer, vessel dilation, wound healing

✉ Email：csyeh@mail.ncku.edu.tw

☎ Phone：06-2757575-65328

Education

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BS in Chemistry, Tamkang University (1984)

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MS in Chemistry, National Tsing Hua University (1986)

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PhD in Chemistry, University of Georgia (1993)

Experience

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1995-2001  National Cheng Kung University, Associate Professor

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2001-2009  National Cheng Kung University, Professor

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2009-2017  National Cheng Kung University, Distinguished Professor

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2017-Present  National Cheng Kung University, Distinguished Chair Professor

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2018-Present  National Cheng Kung University, Department Chair

Publications

  1. Pan, W. C.; Luo, C. H.; Lin, W. L.; Wang, L. C.; Manoharan, D.; Chang, P. Y.; ... & Yeh, C. S.*“Enhanced Catalytic Cycle of Glucose Oxidation and Reactive Species with ROS and RHS Generation Mediated by Galvanic Engineering of Dual Atomic Sites on Covalent Organic Frameworks Demonstrating Synergistic Bimetal Tumor Treatment.” Adv. Sci., 2025, e00515.

  2. Chen, Y. C.; Chang, L. C.; Liu, Y. L.; Chang, M. C.; Liu, Y. F.; Chang, P. Y.; ... & Yeh, C. S.* “Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy.” Nat. Commun. 2025, 16(1), 3253.

  3. Wang, L. C.; Kuo, Y. C.; Kuo, Y. T.; Chang, K. L.; Chen, Y. C.; Wang, W. J.; ... & Yeh, C. S.* “Utilizing Electron‐Sink‐Enhanced Nanoshells for Amplified Nanoplasmonic SERS‐Based In Situ Detection of Cancer Cells, Linking Signal Enhancement with Cellular Damage.” Adv. Mater. 2025, 2417950.

  4. Wang, L. C.; Chang, L. C.; Huang, H. L.; Chang, P. Y.; Pao, C. W.; Liu, Y. F.; ... & Yeh, C. S.*“Synergistic ROS Generation via Core–Shell Nanostructures with Increased Lattice Microstrain Combined with Single-Atom Catalysis for Enhanced Tumor Suppression.”ACS Appl. Mater. Interfaces. 2024, 16 (34), 45356-45370. 

  5. Wang, L. C.; Chen, H. K.; Wang, W. J.; Hsu, F. Y.; Huang, H. Z.; Kuo, R. T.; Li, W. P.*; Tian, H. K.* & Yeh, C. S.* "Boosting Upconversion Efficiency in Optically Inert Shelled Structures with Electroactive Membrane through Electron Donation." Advanced Materials, 2024, 2404120.

  6. Manoharan, D.; Wang, L. C.; Chen, Y. C.; Li, W. P.* & Yeh, C. S.* "Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics."  Advanced Healthcare Materials, 2024, 2400746.

  7. Wang, L.C.; Chiou, P.Y.; Hsu, Y.P.; Lee, C.L.; Hung, C.H.; Wu, Y.H.; Wang, W.J.; Hsieh, G.L.; Chen, Y.C.; Chang, L.C.; Su, W.P.; Manoharan, D.; Liao,M.C.; Thangudu,S.; Li, W.P.; Su, C.H.; Tian; H.K.; Yeh, C.S.* " Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments" Nature Communications, 2023, 14, 4709.

  8. Chen, Y.C.; Li, Y.T.; Lee, C.L.; Kuo, Y.T.; Ho, C.L.; Lin, W.C.; Hsu, M.C.; Long, X.; Chen, J.S.; Li, W.P.; Su, C.H.; Okamoto, A.; Yeh, C.S.* " Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy" Nature Nanotechnology, 2023, 18, 1492-1501.

  9. Wang, L.C.; Chang, L.C.; Chen, W.Q.; Chien, Y.H.; Chang, P.Y.; Pao, C.W.; Liu, Y.F.; Sheu, H.S.; Su, W.P.; Yeh, C.H.; Yeh, C.S.* "Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy" Nature Communications, 2022, 13, 7772.

  10. Yagi, J. ; Ikeda, A. ; Wang, L.C. ; Yeh, C.S.*; Kawasaki, H.* " Singlet Oxygen Generation Using Thiolated Gold Nanoclusters under Photo- and Ultrasonic Excitation: Size and Ligand Effect"  J. Phys. Chem. C , 2022, 126, 46, 19693–19704.

  11. Chen, Y.C.; Liu, Y.J. ; Lee, C.L.; Pham, K.Y.; Manoharan, D.; Thangudu, S. ; Su, C.H.*; Yeh, C.S.* "Engineering H2O2 and O-2 Self-Supplying Nanoreactor to Conduct Synergistic Chemiexcited Photodynamic and Calcium-Overloaded Therapy in Orthotopic Hepatic Tumors" Adv. Healthc. Mater., 2022, 11, 20, 2201613.

  12. Su, W.P.*; Chang, L.C.; Song, W.H.; Yang, L.X.; Wang, L.C.; Chia, Z.C.; Chin, Y.C. ; Shan, Y.S.; Huang, C.C.*; Yeh, C.S.*" Polyaniline-Based Glyco-Condensation on Au Nanoparticles Enhances Immunotherapy in Lung Cancer" ACS Appl. Mater. Interfaces, 2022, 14, 21, 24144–24159.

  13. Wang, L.C.; Chang, L.C.; Su, G.L.; Chang, P.Y.; Hsu, H.F.; Lee, C.L.; Li, J.R.; Liao, M.C.; Thangudu, S.; Treekoon, J.; Yu, C.C.; Sheu, H.S. *; Tu, T.Y. *; Su, W.P.*; Su, C.H.* ; Yeh, C.S.*" Chemical Structure and Shape Enhance MR Imaging-Guided X-ray Therapy Following Marginative Delivery" ACS Appl. Mater. Interfaces, 2022, 14, 11, 13056–13069.

  14. Guo, L.Z.*; Wu, C.H.*; Tsai, M.F.; Cheng, F.Y. ; Shanmugam, V.; Tsai, Z.U.; Zhang, Z.M.; Liu, T.M.*; Yeh, C.S.*" Plasmon Resonant Two-Photon Luminescence Inducing Photosensitization and Nonlinear Optical Microscopy In Vivo by Near-Infrared Excitation of Au Nanopeanuts" Appl. Sci., 2021, 11, 22, 10875.

  15. Luo, C.H.*; Hsu, Y.H.; Wu, W.J.; Chang, K.C.; Yeh, C.S.*"Phage Digestion of a Bacterial Capsule Imparts Resistance to Two Antibiotic Agents" Microorganisms., 2021, 9, 4, 794.

  16. Divinah Manoharan; Li-Chan Chang; Yan-Shen Shan; Forn-Chia Lin; Lai-Chin Wu; Hwo-Shuenn Sheu; Wen-Pin Su*; Yeh, C.S.* "Synchronization of Nanoparticle Sensitization and Radiosensitizing Chemotherapy through Cell Cycle Arrest Achieving Ultralow X-ray Dose Delivery to Pancreatic Tumors" ACS Nano, 2021, 15, 5, 9084-9100.

  17. Pham, K. Y.; Wang, L. C.; Hsieh, C. C.; Hsu, Y. P.; Chang, L. C.; Su, W. P.; Chien, Y. H.*; Yeh, C. S.* "1550 nm excitation-responsive upconversion nanoparticles to establish dual-photodynamic therapy against pancreatic tumor" J. Mater. Chem. B, 2021, 9, 694-709.

  18. Kaur, K.; Bindra, P.; Mondal, S.; Li, WP; Sharma, S.; Sahu, B.K.; Naidu, B.S.; Yeh, C.S.; Gautam, U.K. ; Shanmugam, V.* “Upconversion Nanodevice-Assisted Healthy Molecular Photocorrection” ACS Biomater. Sci. Eng., 2021, 7, 1, 291–298.

  19. Lee, I. J.; Kao, P. T.; Hung, S. A.; Wang, Z. W.; Lin, H. J.; Chang, W. T.; Yeh, C. S.*; Liau, Ian* “Light triggering goldsomes enable local NO-generation and alleviate pathological vasoconstriction” Nanomedicine: NBM 2020, 30, 10228

  20. Pu, Y. C.*; Wang, L. C.; Wu, S. N.; Chang, J. C.; Yeh, C. S.* "Aspect Ratio Dependent Charge Carrier Dynamics in Matchstick-like Ag2S-ZnS Nanorods for Solar Hydrogen Generation" J. Phys. Chem. Lett., 2020, 11, 2150-2157.

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